A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation.
Cyclin D1 regulates Collections G1 progression.Its transcriptional regulation is well understood.However, the mechanism underlying cyclin D1 ubiquitination and its subsequent degradation is not yet clear.We report that cyclin D1 undergoes increased degradation in the cytoplasm during S phase in a variety of cancer cells.This is mediated by phosphor